1.
Indian J Exp Biol
;
1989 Nov; 27(11): 1005-7
Article
in English
| IMSEAR
| ID: sea-55898
ABSTRACT
UV-irradiation (0.6 J/m2) of peripheral human leukocytes 27 hr after PHA-stimulation induced a considerable mitotic delay in the cultures. Approximately two thirds of the chromosomal aberrations induced by UV were gaps of the chromatid and isochromatid types. Treatment with glucose antimetabolite 2-deoxy-D-glucose (2-DG) alone did not induce any chromosomal damage. Presence of 2-DG (5 mM, equimolar with glucose) for 2 hr after UV-irradiation resulted in a significant reduction in the frequency of cells with aberrations. Decrease in the total aberrations per cell was also observed. The data are consistent with earlier observations that 2-DG reduces the manifestation of radiation damage in normal proliferating cells.
Subject(s)
Adult , Cells, Cultured , Chromosome Aberrations , Deoxy Sugars/pharmacology , Deoxyglucose/pharmacology , Humans , Leukocytes/cytology , Male , Mitosis/radiation effects , Phytohemagglutinins/pharmacology , Ultraviolet Rays
2.
Indian J Biochem Biophys
;
1988 Oct; 25(5): 416-21
Article
in English
| IMSEAR
| ID: sea-28360
3.
Article
in English
| IMSEAR
| ID: sea-25897
4.
Indian J Biochem Biophys
;
1986 Dec; 23(6): 344-7
Article
in English
| IMSEAR
| ID: sea-26592
5.
Indian J Biochem Biophys
;
1986 Jun; 23(3): 127-32
Article
in English
| IMSEAR
| ID: sea-28794
6.
Article
in English
| IMSEAR
| ID: sea-24952
7.
Indian J Biochem Biophys
;
1985 Apr; 22(2): 65-70
Article
in English
| IMSEAR
| ID: sea-28242
8.
Indian J Exp Biol
;
1982 Dec; 20(12): 884-8
Article
in English
| IMSEAR
| ID: sea-59185
9.
Indian J Exp Biol
;
1981 Mar; 19(3): 231-7
Article
in English
| IMSEAR
| ID: sea-63345
10.
Indian J Exp Biol
;
1977 Sep; 15(9): 711-3
Article
in English
| IMSEAR
| ID: sea-56630